Techno-entrepreneurship is a multidisciplinary and recent field which is growing. In this research the concepts and meaning of entrepreneurship and technology is reviewed and theories of Techno-entrepreneurship is investigated. The model of prodan for Techno-entrepreneurship is presented. This model comprises seven Key Elements including: Technological Entrepreneur, Universities, Corporations, Capital, Market/Customers, Government and finally Advisors. The next section of paper, the entrepreneurship in the biotechnology as one case of Techno-entrepreneurship is investigated. According to the characterizations of the biotechnology industry, Bioentrepreneur is defined. Funding of biotechnology company, opportunity assessment through feasibility process and Micro-level Analysis and finally alternative commercialization options and pathways to market like Spin-off, traditional out-licensing of technology or IP, trade sale and internal development are studied. This study should aid researchers, form the basis for future research and serve as a guide for governments and regions willing to develop and stimulate biotechnological entrepreneurship. At the end, the paper is presented some suggestion in the related areas.